CALL FOR PAPERS Physiology and Pharmacology of Temperature Regulation Central endothelin ETB receptors mediate IL-1-dependent fever induced by preformed pyrogenic factor and corticotropin-releasing factor in the rat
نویسندگان
چکیده
Aline S. C. Fabricio, Giles A. Rae, Aleksander R. Zampronio, Pedro D’Orléans-Juste, and Glória E. P. Souza Laboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil; Department of Pharmacology, Biological Sciences Center, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil; Department of Pharmacology, Biological Sciences Section, Universidade Federal do Paraná, Curitiba, Paraná, Brazil; Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
منابع مشابه
Endothelin-an emerging role in proinflammatory pathways in brain.
AS ONE OF THE MOST COMMON symptoms of infectious disease, fever has been intensively studied over the past 75 years. An understanding of the cascade of events leading from bacterial invasion of the body to the development of an elevated body temperature began to emerge in the 1970s and early 1980s. A mechanism was envisioned whereby the active component of bacterial cell walls, LPS, interacts w...
متن کاملCentral Effects of TNFo on Thermogenesis and Fever in the Rat
Intracerebroventricular (icv) injection of purified recombinant human tumour necrosis factor ol (TNFol, 4-8#g) in conscious rats, produced increases in colonic temperature (1.0~ and resting oxygen consumption (VO 2, 14%) which were maximal after 80-90 minutes. Pretreatment with propranolol (10 mg/kg s.c.) significantly inhibited the rise in VOa, and prevented the increase in body temperature. I...
متن کاملCannabinoid CB1 Receptors Mediate the Gastroprotective Effect of Neurotensin
Objective(s) Several lines of evidence indicate that neuropeptides exhibit protective properties against gastroduodenal ulcers. Neurotensin, a gut-brain neuropeptide, is implicated in a number of physiological processes in the central nervous system and peripheral tissues including gastrointestinal tract. In the present study, we aimed to investigate the gastroprotective potential of either p...
متن کاملAdministration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
Objective(s): Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study was performed to investigate the role of rostral ventromedial medulla (RVM) orexin receptor 1 in stress-induced analgesia (SIA). Materials and...
متن کاملCALL FOR PAPERS Physiology and Pharmacology of Temperature Regulation Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats
Fabricio, Aline S. C., Giuseppe Tringali, Giacomo Pozzoli, Miriam C. Melo, Juliana A. Vercesi, Gloria E. P. Souza, and Pierluigi Navarra. Interleukin-1 mediates endothelin-1-induced fever and prostaglandin production in the preoptic area of rats. Am J Physiol Regul Integr Comp Physiol 290: R1515–R1523, 2006. First published February 2, 2006; doi:10.1152/ajpregu.00604.2005.—The intracerebroventr...
متن کامل